Oxidation of fatty acids with an odd number of carbons

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In addition to AcCoA, propionyl-CoA is also formed by oxidation of odd-chain fatty acids. This is first carboxylated to methylmalonyl-CoA', which is converted to succinyl-CoA - an intermediate of the Krebs cycle'. Through conversion to oxaloacetate, it can participate in gluconeogenesis - glucose can be synthesized from these fatty acids. However, very few fatty acids with an odd number of carbon atoms are found in the body.

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• Oxidation of very long chain fatty acids
• Oxidation of unsaturated fatty acids
• Regulation of beta-oxidation of fatty acids
• Lipid breakdown and ketone body metabolism

Source

Fontana J., Trnka J., Maďa P., Ivák P. et al.: Transformation of substances and energy in the cell. In: Functions of cells and the human body : Multimedia scripts. Available online from: [1]