Parameters of liver synthetic function

We will assess the parameters of the synthetic function of the liver by evaluating plasma proteins.

Electrophoresis[edit | edit source]

For more information see Electrophoresis.

Electrophoresis of serum proteins

Today electrophoresis has more of a screening character, mainly when searching for gammopathy (paraprotein). From the liver point of view, we monitor albumin or α, β globulins.

Previously, electrophoresis was used to evaluate inflammation:

beginning of inflammation - α1, α2 increased
late inflammation - α2 and γ increased
chronic inflammation – γ increased
acute exacerbation chr. of inflammation - α1, α2 and γ increased

For more information see Serum protein electrophoresis.

Prealbumin[edit | edit source]

It is a transport protein for T3 and T4, in complex with it is RBP, retinol binding protein - carries vitamin A. The half-life of prealbumin is 12 h. A decrease is an early and sensitive indicator of protein malnutrition (loss through the intestines, kidneys or malabsorption). Only with HD the levels rise.

Albumin[edit | edit source]

For more information see Albumin.

Quantitative assessment with an albumin half-life of 15-19 days. The Liver has a large proteosynthetic reserve → when it is already decreasing, the disease is already developed. Albumin is used more for long-term monitoring of the course of diseases.

Main causes of hypalbuminemia:

reduced synthesis - primarily - liver diseases, secondarily with low AMK intake
increased catabolism
protein losses – urine, DM, lupus, stool, skin
reduced resorption of AMK by the intestine - malabsorption
sequestration of albumin into the third space (ascites)

Hyperalbuminemia - caused purely by dehydration.

Oromucoid[edit | edit source]

It is an acute phase protein (see there). It decreases in malnourished women.

Transferin[edit | edit source]

Transferin is determined for the differential diagnosis of anemia and for monitoring treatment. It is a negative acute phase protein.

CDT transferrin – it is changed in alcoholics and in pregnancy, in the West it is determined when hiring...

C-reactive protein and other acute phase proteins[edit | edit source]

For more information see C-reactive protein.

For more information see Acute Phase Proteins.

Links[edit | edit source]

References[edit | edit source]

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  Incomplete site citation. SCHNEIDERKA, Peter, et al. Karolinum, ©2004.

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