Serotonin
From WikiLectures
| Gland | GIT; neurotransmitter in brain |
|---|---|
| Structure | biogenic amine |
| Target organ/tissue | digestive tract, platelets, brain |
| Receptor | serotonin (5-HT1-7) |
Serotonin, or 5-hydroxytryptamine, is a substance that is mainly found in the enterochromaffin cells of the alimentary canal and in blood platelets, and in smaller quantities also in the brain. It is therefore a hormone (endocrine secretion in the digestive tract) and a neurotransmitter (secretion in the CNS). Serotonin is derived from the amino acid tryptophan, which is why it ranks among the so-called biogenic amines. The effects of serotonin include:
- platelet aggregation,,
- contraction of smooth muscle, especially vasoconstriction and stimulation of peristalsis of the digestive tract,
- inducing nausea and vomiting by acting on the area postrema,
- affecting mood (depression is associated with a lack of serotonin),
- pain suppression
Serotonergic neurons in the brain likely play an important role in altering circadian rhythms and inducing sleep
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- GANONG, William F. Přehled lékařské fyziologie. 20. vydání. Praha : Galén, 2005. 890 s. ISBN 80-7262-311-7.GANONG, William F. Přehled lékařské fyziologie. 20. edition. Praha : Galén, 2005. 890 pp. ISBN 80-7262-311-7.
- GUYTON, Arthur C. a John E HALL. Textbook of Medical Physiology. 10. vydání. Philadelphia, Pa. : W. B. Saunders, 2000. ISBN 978-0721686776.GUYTON, Arthur C. – HALL, John E. Textbook of Medical Physiology. 10. edition. Philadelphia, Pa. : W. B. Saunders, 2000. ISBN 978-0721686776.
