Type 2 diabetes mellitus (biochemistry)
Type 2 is the predominant form of DM. Patients are not vitally dependent on exogenous insulin because insulin production is not reduced or is reduced less than in type 1 DM .
The cause of this type is a breakdown in the action of insulin . This is the so-called insulin resistance due to a disorder of the insulin receptor or a disorder in the transmission of the insulin signal to the cell.
Insulin levels in the blood tend to be increased initially due to insulin resistance . In the further course of the disease, a disorder of insulin secretion also begins , β-cells gradually lose the ability to respond to increased glucose levels by insulin synthesis.
The disease manifests itself mainly in adulthood, usually over the age of 40. Type 2 DM has a high heredity, so the family burden is evident in the anamnesis. Unlike type 1, patients are not prone to ketoacidosis. 60-90% is associated with obesity.
Links[edit | edit source]
Related Articles[edit | edit source]
- Diabetes mellitus •Diabetes mellitus (pediatrics) •Gestational diabetes mellitus •Newborn diabetic mother
- Type 1 diabetes mellitus (endocrinology) •Type 1 diabetes mellitus (biochemistry)
- Type 2 diabetes mellitus (endocrinology) •Type 2 diabetes mellitus (biochemistry) •Type 2 diabetes mellitus (pediatrics)
- Complications of diabetes mellitus
- Diabetes and tumors • Transplantation in diabetology • Pancreatic transplantation
- Metabolic syndrome and insulin resistance
- Diabetic ketoacidosis / case report
- Diabetic education • Self-monitoring of glycemia
