Verrucous Carcinoma
Verrucous carcinoma (Carcinoma verrucosum) is a highly differentiated variant of squamous cell carcinoma of the skin, which is characterized by slow growth and a warty surface.
It is an invasive carcinoma, but has very little tendency to metastasize.
Epidemiology[edit | edit source]
It occurs mainly in elderly patients in areas with scars, chronic wounds, and chronic venous insufficiency. In some cases, an association with HPV 6 and 11 has been demonstrated.
Clinical Picture[edit | edit source]
There are four forms, mostly according to location.
| Clinical Picture | Location | |
|---|---|---|
| 1. Epithelioma cuniculatum | A large cauliflower formation permeated with tunnels and crypts, later a greasy material can be expelled from the formation. Metatarsal bones can be damaged. | Most often in old men on the soles of the feet. |
| 2. Papillomatosis cutis carcinoides (Skin verrucous carcinoma) | Restricted deposits up to the size of a palm with hyperkeratosis and cauliflower vegetation that do not heal for years. | On the lower legs in places with chronic venous insufficiency or in the vicinity of ulcers. |
| 3. Oral florid papillomatosis | Leukoplactic deposits with papillomatous surface, on the mucosa. It can grow up to the mandible and cause difficulty eating and speaking. Poor oral hygiene, alcoholism, tobaccoism are predisposing conditions. | Surface of the oral cavity, lips, larynx. |
| 4. Large Condylomas (Buschke-Löwenstein) | Gray to pink sessile cauliflower formations. They are very invasive. | On the penis, vulva and perianogenital region. |
Diagnosis[edit | edit source]
Histological. It is an asymmetrically proliferating formation into the epidermis. Contains keratin-filled crypts.
Therapy[edit | edit source]
Surgical treatment is necessary. It is supplemented by radiotherapy, chemotherapy, laser destruction of the tumor, total treatment with retinoids, or interferons.
Links[edit | edit source]
Related Articles[edit | edit source]
- Malignant tumors: Melanoma | Bazocelular carcinoma | Spinocelular carcinoma
- Benign skin tumors
- Precancerous lesions in dermatology
Bibliography[edit | edit source]
- ŠTORK, Jiří. Dermatovenerologie. 1. edition. 2008. 502 pp. ISBN 978-80-7262-371-6.
