Gonosomal recessive inheritance

An example of a family tree with a gonosomally recessive trait

Gonosomal recessive inheritance is the transmission of the observed trait, the allele oh which lies gonosome, namely chromosome X (X-linked inheritance). Few genes are located on the chromosome Y, eg. SRY. The increased pubic hair previously reported as an example of a Y-linked trait (OMIM: 425500), is probably not strongly linked to the Y chromosome.

A typical manifestation is a far greater number of sick men than women, who are overwhelmingly only healthy carriers.

Deviations[edit | edit source]

Some inconsistencies may arise because carriers have different degrees of disease manifestation. It is caused by random lyonization of one of the X chromosomes in each cell of the body. This can occur, for example, in hemophilia.

Examples[edit | edit source]

Hemophilia A (OMIM: 306700)
Hemophilia B (OMIM: 306900)
Color blindness (OMIM: 303800)
Duchenne muscular dystrophy (OMIM: 310200)
Becker muscular dystrophy (OMIM: 300376)

Links[edit | edit source]

Related links[edit | edit source]

Monogenically inherited diseases
autosomally inherited diseases	autosomal dominant inheritance	autosomal inherited agammaglobulinemia • achondroplasia • Apert syndrome • brachydactyly • familial hypercholesterolemia • Huntington's chorea • Marfan syndrome • myotonic dystrophy • neurofibromatosis • osteogenesis imperfecta (late form) • polycystic kidney disease • polydactyly • Thomsen syndrome
autosomally inherited diseases	autosomal recessive inheritance	autosomal inherited agammaglobulinemia • Ataxia telangiectasia • cystic fibrosis • phenylketonuria • Friedreich's ataxia • osteogenesis imperfecta (early form) • polycystic kidney disease • galactosemia • glycogenoses • congenital adrenal hyperplasia • sickle cell anemia • Hurler syndrome • Tay-Sachs disease • Thomsen syndrome • thalassemia • Werdnig-Hoffmann disease • Wilson disease
gonosomally inherited diseases	gonosomal dominant inheritance	incontinentia pigmenti • vitamin D-resistant rickets
	gonosomal recessive inheritance	Becker muscular dystrophy • Bruton's agammaglobulinemia • color blindness • Duchenne muscular dystrophy • hemophilia A • hemophilia B • Wiskott-Aldrich syndrome
	Y-linked inheritance	--