Metabolism of AMK groups of pyruvate and oxaloacetate

Among the AMKs that we classify in the group of ``pyruvate and ``oxalacetate are: threonine, glycine, serine , alanine, cysteine, aspartate, asparagine. Pyruvate and oxaloacetate are important later in the citrate cycle.

Pyruvate group

• Threonine is converted to glycine and acetaldehyde by threoninaldolase. Acetaldehyde can be further dehydrogenated and converted to acetyl-CoA in the presence of coenzyme A. Acetyl-CoA can be used in β-oxidation.
• 'Glycine is converted by the enzyme ``serine hydroxymethyltransferase into serine, which can be converted back by ``threoninaldolase and using THF (tetrahydrofolate, group acceptor) glycine.
• 'Serine is converted to pyruvate in a reaction catalyzed by ``serine dehydratase and H₂O and NH₄^{++ are released Vulture>.}
• Alanine is transaminated with the help of ALT (alanine aminotransferase). In this reaction, the amino group is reversibly transferred from alanine to 2-oxoglutarate to form pyruvate and glutamate.
• Cysteine loses NH₃ releasing H₂S or SO₃^2- and pyruvate is formed.

Oxalacetate group

• Asparagine is converted to aspartate by hydrolytic deamination, when H₂O is supplied and NH₄ is released.
• Aspartate is converted to oxaloacetate by transamination using AST (aspartate aminotransferase).

Links

Related Articles

• β-oxidation
• Amino Acids
• Pyruvate

References

• ws:Metabolismus AMK skupiny pyruvátu a oxalacetátu
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