Side effects of antibiotics
Side effects occur at the usual doses and recommended plasma pharmacotherapeutic concentrations. Toxic effects occur at high doses, due to high plasma concentrations, possibly at higher patient sensitivity. In most cases, they can be prevented or their clinical manifestations alleviated. The risk of toxic effects is acceptable given life-threatening diseases unless another, safer antibiotic is available. The biological effects of antibiotics are caused by a change in the natural bacterial microflora of the skin or mucous membranes. They are especially common when using broad-spectrum antibiotics (ampicillin, tetracyclines).
Allergic reaction[edit | edit source]
Induced after previous sensitization with a small dose of antibiotics. They are common in beta-lactams. Therefore, it is necessary to look for them in the patients history. Clinical manifestations may vary from polymorphic rashes, to urticaria, eosinophilia, edema, fever, conjunctivitis, photodermatoses, bronchial asthma attacks and anaphylactic shock. Dangerous forms are mainly associated with parenteral administration of antibiotics. They may manifest as early or late reactions during or after treatment (after 9-11 days). Due to topical administration, contact allergy (neomycin) may also be encountered.
Effects on the nervous system[edit | edit source]
Effects on the musculoskeletal system[edit | edit source]
Effect on the GIT[edit | edit source]
Effect on the hematopoietic system[edit | edit source]
Effect on the cardiovascular system[edit | edit source]
Nephrotoxicity[edit | edit source]
Links[edit | edit source]
Related articles[edit | edit source]
External links[edit | edit source]
- Rational antibiotic therapy - interactive algorithm + test
- Antibiotics (Czech wikipedia)
- Antibiotic treatment according to diagnoses
Source[edit | edit source]
- MARTÍNKOVÁ, J, S MIČUDA a J CERMANOVÁ. Antibiotika [online]. [cit. 2010-02-18]. <https://www.lfhk.cuni.cz/farmakol/predn/bak/kapitoly/atb-bak.doc/>.
Bibliography[edit | edit source]
- VOTAVA, Miroslav. Lékařská mikrobiologie obecná. 2. edition. Brno : Neptun, 2005. ISBN 80-86850-00-5.
- MARTÍNKOVÁ, Jiřina. Farmakologie pro studenty zdravotnických oborů. 2. edition. Praha : Grada, 2018. ISBN 978-80-271-0929-6.
- ŠVIHOVEC, Jan. Farmakologie. 1. edition. Praha : Grada, 2018. ISBN 978-80-271-2150-2.
- LINCOVÁ, Dagmar. Základní a aplikovaná farmakologie. 1. edition. GALÉN, 2002. ISBN 80-7262-168-8.
